A study coordinated by the UAB and in collaboration with the ULL reveals the biological relevance of sex in the alteration of behaviour and the neuro-immuno-endocrine system, caused by accelerated ageing with a chronic treatment of D-galactose, a sugar found abundantly in milk and in some fruits and vegetables. The research was recently published in the Journal of Gerontology: Biological Sciences and Medical Sciences.
For almost two decades, chronic treatments with D-galactose have been used as a tool to create animal models of accelerated ageing. Their neurotoxicity is due to abnormal ROS accumulation, molecules proper of oxidative stress and AGEs, proteins or lipids which become glycated as a result of exposure to sugars, both related to the acceleration of the multisystem functional decline occurring during ageing. These D-galactose induced biological products are also involved in the development or deterioration of many degenerative diseases such as diabetes, arteriosclerosis, kidney diseases, infections and Alzheimer's disease.
Difficulty - Research - Models - Lies - Fact
"The difficulty in research with accelerated ageing models using D-galactose lies in the fact that its neurotoxicity effects at biochemical level do not always translate into or are observable as pathological symptoms at behavioural level. In the study we found convincing evidence of some of them and observed important differences between the males and females," says Dr Lydia Giménez-Llort, lead researcher of the project.
Through a complete and multifunctional behavioural analysis researchers examined the chronic effects of low (50 mg/kg) and high (100 mg/kg) doses of D-galactose in male and female mice aged 6 months -- the equivalent of 40 human years. Based on the results of twelve tests they assessed the sensory, motor, emotional and cognitive fields and also explored the effects on the neuro-immuno-endocrine system, decisive in pinpointing the vital capacity or biological age of individuals.
Results - Point - Existence - Sensitivity - Thresholds
The results point to the existence of different sensitivity thresholds depending on the...
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