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Scientists at Tokyo Institute of Technology (Tokyo Tech) have found that eukaryotic and bacterial growth regulation systems of independent origins are connected to the control of chloroplast rRNA transcription in a primitive red alga.
Chloroplasts are crucial specialized structures within cells that generate energy and produce storage- and cell metabolism-related molecules that underpin cell growth. The reactions that take place in chloroplasts require the formation of proteins by the chloroplast ribosome (site of protein synthesis in the organelle); however, how this is regulated in plant cells is still largely unknown. The conversion of ribosomal DNA to ribosomal RNA (rRNA), i.e., transcription, is thought to be a rate-limiting step of biogenesis (the slowest step that determines the speed of the ribosome biogenesis), and hence it is crucial to clearly understand rRNA transcription.
Studies - TOR - Target - Rapamycin - Protein
Previous studies have revealed that inhibiting TOR (target of rapamycin), a highly conserved protein kinase, represses nuclear rRNA transcription in many eukaryotes. Associate Professor Sousuke Imamura and colleagues hypothesized that TOR regulates rRNA transcription in chloroplasts and mitochondria. They found that TOR modulates the...
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