"This is the first study to provide evidence that may help clinicians select an initial treatment for infants whose epilepsy does not conform to a known syndrome, which accounts for more than half of infants with epilepsy," said senior author Anne T. Berg, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago. "Our findings suggest that a change in practice could meaningfully improve outcomes for these babies. Since there are no randomized controlled trials to guide treatment for nonsyndromic epilepsy in this age group, we are excited that evidence-based care is now possible for this population."
The observational study, which used robust comparative effectiveness methods, included 155 infants with nonsyndromic epilepsy treated at one of 17 medical centers in the U.S. participating in the Pediatric Epilepsy Research Consortium. The infants in the study had their first non-fever-related seizure between one month and one year of age, and...
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"However, when the Son of Man comes, will he find faith on the earth?" Luke 18:8