New insight into workings of building blocks of life

ScienceDaily | 2/12/2018 | Staff
aniki (Posted by) Level 3
The human genome contains thousands of genes, but to get the information from a gene requires it to be copied.

This copying process -- or transcription -- involves a factory molecule called RNA polymerase that attaches to DNA at the beginning of a gene, copies the information in the gene into an RNA molecule before finally terminating the transcription process at the end of a gene.

Set - Instructions - Place - Message - Case

As with any set of instructions, it is vital to start and stop in the correct place or else the message, in this case the RNA transcript, may make no sense or even cause harm.

A team of researchers, led by Dr Steven West from the University of Exeter's Living Systems Institute, has taken a crucial step towards understanding how the transcription process stops -- or is terminated.

Study - Genes - Development - Thursday - February

The study is published in Genes & Development on Thursday February 8 2018.

Dr West, an Associate Professor in Molecular Biology at the University of Exeter explained: "There have been two models used to explain this. The first, called the allosteric model, suggests that the properties of RNA polymerase are changed at the ends of genes to cause it to stop.

Model - Torpedo - Model - Ends

"The second model is referred to as the torpedo model and proposes that, at the ends...
(Excerpt) Read more at: ScienceDaily
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