Synthesis of a water-soluble warped nanographene and its application for photo-induced cell death

phys.org | 2/9/2018 | Staff
xhelloworld (Posted by) Level 4
Click For Photo: https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/2018/5a7dbc2a3b16d.jpg

Graphene and its nano-sized little sibling, nanographene, are well known for their remarkable photoelectronic properties. However, biomedical applications are hampered by the insolubility of the materials, especially in water. A Japanese team of scientists has now introduced substituted "warped nanographene," which is soluble in a broad range of solvents while maintaining its photophysical properties. In their publication in Angewandte Chemie, the authors also emphasize its photodynamic potential to selectively kill cells upon irradiation.

Nanographene has the hexagonal carbon lattice of graphene but consists of only a few carbon rings with tunable electronic properties. One of its big issues hampering widespread application in optoelectronic devices or biomedicine is its insolubility. Therefore, to suppress stacking and aggregation, a new type of nanographene with a bended structure has been synthesized, the so-called warped nanographene. Kenichiro Itami at Nagoya University, Japan, and his colleagues have now found a way to furnish the warped nanographene even further to obtain a fully soluble, amphiphilic product. The new structure was biocompatible, but upon irradiation it killed its host cell. This effective photosensitization behavior could inspire future research in photodynamic cancer therapy, the authors believe.

Solubility - Materials - Discovery - Graphene - Carbon

The poor solubility of graphene-like materials has been regarded problematic since the discovery of graphene as an intriguing one-layer carbon modification in 2004. To improve solubility, Itami and his colleagues have developed warped nanographene molecules with chemical substituents at the outer...
(Excerpt) Read more at: phys.org
Wake Up To Breaking News!
"However, when the Son of Man comes, will he find faith on the earth?" Luke 18:8
Sign In or Register to comment.

Welcome to Long Room!

Where The World Finds Its News!