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The network of blood vessels in the brain regulates the transport of energy and materials in and out of the brain -- forming what is known as the blood-brain barrier (BBB). Scientists working in the Smurfit Institute of Genetics at Trinity College Dublin and the Department of Psychiatry, RCSI, have discovered that abnormalities in the integrity of the BBB may be a critical component in the development of schizophrenia and other brain disorders.
The research, published today in the leading international journal Molecular Psychiatry, was supported by the Health Research Board (HRB), Science Foundation Ireland (SFI) and the US-based charity, Brightfocus Foundation.
People - Abnormality - Deletion - Syndrome - Times
People living with a chromosomal abnormality termed '22q11 deletion syndrome' (22q11DS) are 20 times more likely to develop schizophrenia. These people lack approximately 40-60 genes within a small region in one of the pairs of chromosome 22. A gene termed "Claudin-5" is located within this region, and it is changes in the levels of this component of the BBB that are associated with the presence of schizophrenia.
Assistant Professor in Neurovascular Genetics at Trinity, Dr Matthew Campbell, said: "Our recent findings have, for the first time, suggested that schizophrenia is a brain disorder...
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