3D bioprinted vascularized liver tissue to increase accuracy of drug toxicity testing

3ders.org | 8/11/2017 | Staff
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An international team of researchers has developed a method for 3D bioprinting vasularized liver tissue. The bioprinting breakthrough could have important applications for drug toxicity testing and drug screening.

In the field of bioprinting, the future looks bright as we expect to one day have access to 3D printed organs and implantable tissues. At the moment, however, researchers in the field are still working to overcome some pretty significant hurdles. One of them, perhaps the most significant, is figuring out how to bioprint vascularized tissues, or tissues with blood vessel systems.

Blood - Vessels - Course - Help - Life

Blood vessels, of course, help to give life to organs and tissues, so vascularization is a crucial part of implanting organic material and having it stay alive inside the body. In recent months though, researchers from a number of places seem to have been making breakthroughs in the field.

For instance, a team of scientists from the University of California San Diego recently announced they had successfully 3D printed a blood vessel network using an ultra-fast bioprinting system, and a team from China reportedly transplanted 3D printed blood vessels into a monkey to promote vascular tissue regeneration.

Project - Researchers - Chile - Italy - Saudi

Even more recently, a collaborative project between researchers from Chile, Italy, Saudi Arabia, Korea, and the United States has resulted in a simple 3D bioprinted vascularized liver tissue. The research study, entitled “Bioprinted 3D vascularized tissue model for drug toxicity analysis,” was published in the journal Biomicrofluidics just days ago.

Bioprinted using a special "sacrificial" bio-ink, the vascularized liver tissue model can be used for more accurate drug toxicity testing. The researchers even say their method for creating the innovative tissue could be adapted for use with different types of cells, which could open the doors for patient-specific drug screening.

Drug - Test - Models - Monolayer - Cell

“Most drug test models use a two-dimensional (2D) monolayer cell tissue, or a 3D...
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