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A low-calorie diet may be key to youth, scientists claim after finding the link between the body's biological clock and aging.
Researchers at the University of California, Irvine, analyzed how aging affects our circadian rhythm - the body's 'clock' - and slowly derails metabolism over time.
Diet - Thing - Cells - Energy-regulation - Process
Ultimately, they found a low-calorie diet was the best thing to keep the cells' energy-regulation process 'humming', keeping the body younger.
Lead author Dr Paolo Sassone-Corsi said the study presents a 'molecular holy grail' that clearly shows the cellular pathway that controls aging.
Findings - Introduction - Elements - Perspective - Dr
'The findings provide a clear introduction on how to go about controlling these elements of aging in a pharmacological perspective,' Dr Sassone-Corsi explained.
The clock-controlled circuit that directly connects to the process of aging is based on the cells efficient metabolism of energy.
Researchers - Group - Mice - Months - Months
The researchers tested the same group of mice at six months and 18 months, drawing tissue samples from the liver, the organ which operates as the interface between nutrition and energy distribution in the body.
They found that older cells processed energy inefficiently.
Group - Mice - Percent - Calories - Months
But in a second group of aged mice that were fed a diet with 30 percent fewer calories for six months, energy was processed in a more stable way.
More simply put, researchers found that calorie meals help the body metabolize energy more efficiently and keep people looking and feeling younger.
Dr - Sassone-Corsi - Director - Center - Epigenetics
Dr Sassone-Corsi, director of the Center for Epigenetics and Metabolism at the university, said: 'This mechanism works great in a young animal, but it basically shuts off in an old mouse.'
He also explained that by restricting caloric intake, the biological clock was rejuvenated.
Things - Calorie - Count - Foods - Things
Things that can be done to reduce daily calorie count are switching out fried foods for things that are baked, opting for fruits and vegetables over starches and carbs, and avoiding sugary drinks in favor of...
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