"We hope that the future development of therapies aimed at preventing or removing the accumulation of aggregated proteins within the aging brain will lead to healthy lifestyles in the elderly by maintaining their cognitive capabilities," said Antonio Currais, Ph.D., a co-author of the work and senior research associate at the Salk Institute for Biological Studies in La Jolla, California. "Our laboratory is very focused on developing therapies for the treatment of neurodegenerative diseases by targeting pathological processes that occur with aging and that we believe are the primary cause of those diseases. This is in direct contrast to the pharmaceutical companies that have focused their drug discovery approaches on very rare genetic forms of these diseases, basically ignoring aging."
In the review, scientists suggest that because nerve cells do not divide and cannot dilute out damaged proteins by distributing them between two new cells, the proteins accumulate...
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