Melting reveals drug targets in a living organism

phys.org | 7/6/2018 | Staff
k.collazik.collazi (Posted by) Level 3
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Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory and Cellzome, a GSK company, has developed a technology to systematically identify drug targets in living animals. In their results, published in Nature Biotechnology on 20 January, the scientists mapped protein-drug interactions in rat organs and blood. Their research opens pathways in drug discovery, fundamental biology, and personalized medicine.

When a drug binds to a protein, the structure of the protein gets tighter and only unfolds at higher temperatures. In this study, Mikhail Savitski—team leader and head of the Proteomics Core Facility at EMBL Heidelberg—and his team, together with a team at Cellzome melted proteins to observe their properties. They were able to get insights into the interactions between multiple proteins, or between proteins and drugs.

Time - Interactions - Organism - View - Drug

"For the first time, we can systematically map drug-protein interactions in a mammalian organism. This global view of the drug targets and potential side-effects is a huge step in drug discovery," explains Mikhail Savitski. By comparing the...
(Excerpt) Read more at: phys.org
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