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Researchers from the Aristotle University of Thessaloniki (AUTh), Greece, have developed 3D printable direct and indirect patches with wound-healing capabilities.
In an article published in the journal Pharmaceutics, 3D printable inks based on pectin, a naturally occurring substance found in berries, apples, and other fruit, which form free‐standing transparent films designed to treat shallow wounds and ulcers.
Application - Dressings - Cotton - Bandages - Gauzes
“The application of traditional dressings, like cotton bandages or gauzes, absorb the moisture contained by the wound, leading to dehydration of the wound surface, and subsequently decreasing the healing rate,” the research states.
“FREE‐STANDING TRANSPARENT FILMS THAT DISINTEGRATE UPON CONTACT WITH AQUEOUS MEDIA WERE DEVELOPED VIA 3D BIOPRINTING [WHERE] THE ANTIMICROBIAL AND WOUND‐HEALING ACTIVITIES OF THE FABRICATED DRESSINGS WERE EFFECTUALLY ENHANCED BY THE INCORPORATION OF PARTICLES.”
3D printed wound-dressings
According to the AUTh team, alternative dressings made from polymers forming films, foams or gels have been frequently used as it provides the optimum conditions for wound‐healing. This is due to its ability to maintain the moisture of a wound which enables pain relief for the patient. Furthermore, traditional dressings can become toxic if not changed within certain time frames.
Systems - Moisture - Environment - Air - Trauma
Thus, wound‐dressing systems were developed that could provide an adequate moisture environment under air and water-tight trauma, otherwise known as occlusive conditions. This dressing also uses natural, non‐toxic bioinks including materials such as apple pectin, manuka honey, and propolis extract, a resin-like material made by bees, to avoid infection and contamination.
This was mixed with dermal fibroblasts cells, which are responsible for generating connective tissue. From these ingredients, the patches were produced using the CELLINK INKREDIBLE 3D bioprinter. This led to an assessment of the...
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