New insights to major disease pathways | 8/10/2016 | Staff
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Flinders researchers have made major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.

The latest publication in ChemBioChem reveals how a chemical tool has been used to identifying 148 previously unknown proteins modified by cells damaged by stress.

Results - Advances - Flinders - University - Chalker

The results build on earlier advances at the Flinders University Chalker Lab, led by nanotechnology researchers Associate Professor Justin Chalker and Dr. Lisa Alcock in collaboration with Dr. Gonçalo Bernardes' lab at the University of Cambridge and Heinrich-Heine-University in Dusseldorf, Germany.

The new modified proteins identified in the latest research are linked to heart disease, drug resistance in cancer, and other critical cellular functions, says Dr. Chalker, director of the Flinders Chalker Research Lab.

Study - Foundation - Network - Proteins - Stress

"This study is an important foundation for understanding the network of proteins that communicate during oxidative stress," he says. "It gives new signposts for biomedical scientists around the world to understand how cells react and respond to reactive oxygen species (ROS)."

ROS can...
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