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It has long been suggested that a cell protease could take part in enterovirus infection. However, the identities of such proteases have remained unknown. The work performed in the University of Jyväskylä shows, for the first time, that host cell calpain proteases can process enterovirus polyprotein in vitro. The research was published in Viruses in November 2019.
Enteroviruses are the most common viruses infecting humans. Although most of the diseases that enteroviruses cause are symptomless or mild, enteroviruses can also cause more severe diseases.
Calpains - Host - Cell - Proteases - Cell
Calpains are common host cell proteases, ubiquitous in the cell cytoplasm. The group of Docent Varpu Marjomäki had shown earlier that inhibition of calpain proteases stops enterovirus infection very efficiently. Their new research sheds light on the mechanism of the inhibitory effect. The work suggests that enteroviruses have learned through evolution to take advantage of cellular resources for their...
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