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RUDN University bioengineers have created magnetic nanocontainers for smart delivery of drugs to the desired organs or tissues, which reduces the risk of side effects. An experiment on mice determined that the nanocontainers are non-toxic. The results of the study are published in the journal Polymers.
Pharmaceutical side effects often occur because the active substance of the drug enters healthy organs. That is why, for example, chemotherapy is so hard for patients in the treatment of cancer: Toxic drugs affect not only tumor cells, but the whole body. Targeted drug delivery systems solve this problem. Many potential carriers have been proposed in recent years: microcapsules with a shell of polyelectrolytes, artificial liposomes of micro- and nanoscale, and protein nanoparticles, for example. Several dozen drugs packed in such containers are already used in practice or are undergoing clinical trials.
Problems - Use - Carriers - Dependence - Drug
However, there are still many problems that prevent the widespread use of smart carriers. One is that the dependence of the drug biodistribution process in tissues dictates the size of containers. The smaller the size, the greater the likelihood that the drug will reach the correct organ, and the lower the dose of the drug is required, reducing toxic effects. Another problem is the lack of information about toxicity, effects on the body and distribution in living tissues. Both of these problems have been successfully solved by the RUDN University biochemists in collaboration with colleagues from Russia and the UK.
Researcher of the Surface Engineering Laboratory of RUDN University Olga Sindeeva and her co-authors created submicron-scale magnetic-sensitive containers –particles of 400-600 nanometers, with a shell of several layers of bovine serum albumin (BSA) with a fluorescent tag Cy7, and tannic acid (TA).
Novelty - Study - Method - Containers - Nanoparticles
The novelty of the study is in the method of obtaining containers, in which nanoparticles of magnetite (MNPs), mixed iron oxide (II, III) were...
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