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Streptomyces bacteria are our primary source of antibiotics, which are produced in the transition from vegetative growth to sporulation in a complex developmental life cycle.
Previous research by Professor Mark Buttner's lab at the John Innes Centre has shown that the signalling molecule c-di-GMP binds BldD, a master repressor of gene activity, to control the initiation of development in these soil-dwelling bacteria.
C-di-GMP - Example - Messenger - Signal - Widespread
c-di-GMP is an example of a nucleotide second messenger, an intracellular signal widespread in bacteria responsible for regulating crucial processes, including mobility, virulence and biofilm formation.
In a new study, experiments using the model species Streptomyces venezuelae show that c-di-GMP also intervenes later in development to control the differentiation of the reproductive hyphae into spores.
Interaction - Sporulation - Sigma - Factor - Streptomyces
It does this by mediating an interaction between the major sporulation sigma factor in Streptomyces, WhiG, and the anti-sigma factor RsiG.
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