Dramatic transition in Streptomyces life cycle explained in new discovery

phys.org | 2/5/2019 | Staff
monnamonna (Posted by) Level 3
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Streptomyces bacteria are our primary source of antibiotics, which are produced in the transition from vegetative growth to sporulation in a complex developmental life cycle.

Previous research by Professor Mark Buttner's lab at the John Innes Centre has shown that the signalling molecule c-di-GMP binds BldD, a master repressor of gene activity, to control the initiation of development in these soil-dwelling bacteria.

C-di-GMP - Example - Messenger - Signal - Widespread

c-di-GMP is an example of a nucleotide second messenger, an intracellular signal widespread in bacteria responsible for regulating crucial processes, including mobility, virulence and biofilm formation.

In a new study, experiments using the model species Streptomyces venezuelae show that c-di-GMP also intervenes later in development to control the differentiation of the reproductive hyphae into spores.

Interaction - Sporulation - Sigma - Factor - Streptomyces

It does this by mediating an interaction between the major sporulation sigma factor in Streptomyces, WhiG, and the anti-sigma factor RsiG.

A sigma...
(Excerpt) Read more at: phys.org
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