Controversial supplement helped to slow aging in cells with a rare aging syndrome

Mail Online | 12/2/2019 | Mia De Graaf Health Editor For
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A controversial anti-aging supplement appeared to slow aging in cells with a rare condition that accelerates aging and kills sufferers by the age of 45.

NAD+ is a pill designed to boost our levels of a molecule called NAD (nicotinamide adenine dinucleotide), which is abundant in children, fuels metabolism, and seems to keep cells fresh.

Decade - Flurry - Excitement - NAD+ - Scores

In the past decade, there has been a flurry of excitement over NAD+, with scores of scientists claiming to have evidence that NAD+ slows aging in animals by fueling new cell creation, and just as many critics saying the evidence is weak.

Now, Danish scientists are joining the debate, with a study that identified possible causes of the aging condition Werner Syndrome, and evidence that NAD+ helped stem the illness, delaying death and aging.

'We - Time - Werner - Syndrome - Errors

'We are showing for the first time that Werner Syndrome is due to errors in the clean-up process,' said lead author Vilhelm Bohr, a professor at the Center for Healthy Aging at the University of Copenhagen.

'When we improve the clean-up by giving supplements of the drug NAD+, we can show in animal models that it increases lifespan and delays the aging processes.'

Werner - Syndrome - Japan - People - United

Werner Syndrome is rare. It most common in Japan, affecting between 1 in 20,000 and 1 in 40,000 people. In the United States, 1 in 200,000 have the condition.

From a young age, sufferers develop grey hair and wrinkled skin. They are more likely to develop cancer and type 2 diabetes, and are unlikely to live to 50.

Researchers - Condition - Boom - Research - Ideas

Researchers still don't know exactly what causes the condition, but a recent boom in research on aging has helped uncover new ideas about why and how cells age.

Dr Bohr's team wanted to look at a process called mitophagy, a useful and necessary 'clean-up' process in the body, which identifies defective mitochondria (a cell's 'battery'),...
(Excerpt) Read more at: Mail Online
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