Potential drug targets for glioblastoma identified

ScienceDaily | 11/5/2019 | Staff
princia (Posted by) Level 3
"We have found disease-related changes in the cells that line the tumour blood vessels, so called endothelial cells, which have long been considered a possible clinical target for cancer treatment," says Lynn Butler, assistant professor at the Department of Molecular Medicine and Surgery, Karolinska Institutet, who led the study. "Proteins only expressed in the endothelial cells of the tumour vessels could be used as targets to attack the tumour's blood supply, or for delivery of therapeutic agents, without affecting the normal brain."

There are more than 200 different cell types in the human body, each performing their own role. Understanding the differences between these cell types helps us understand how organs work and how cells change in disease. Cell identity is determined by the specific proteins expressed, which can be predicted by measuring the protein transcripts found inside the cell. For the study,...
(Excerpt) Read more at: ScienceDaily
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