Click For Photo: https://scx2.b-cdn.net/gfx/news/2019/bacteriallif.jpg
Bacteria forming a biofilm on a plastic bead. Credit: Vaughn Cooper, Ph.D.
How bacteria live—whether as independent cells or in a communal biofilm—determines how they evolve antibiotic resistance, which could lead to more personalized approaches to antimicrobial therapy and infection control.
University - Pittsburgh - School - Medicine - Researchers
University of Pittsburgh School of Medicine researchers repeatedly exposed bacteria to the antibiotic ciprofloxacin to force rapid evolution. As expected, the bacteria developed resistance to the drug, but surprisingly, their lifestyle affected which specific adaptations emerged, according to a study published today in eLife.
"What we're simulating in the lab is happening in the wild, in the clinic, during the development of drug resistance," said senior author Vaughn Cooper, Ph.D., director of the Center for Evolutionary Biology and Medicine at Pitt. "Our results show that biofilm growth shapes the way drug resistance evolves." According to study lead author Alfonso Santos-Lopez, Ph.D., a postdoctoral researcher in Cooper's lab, this finding could uncover vulnerabilities that may prove useful when treating drug-resistant infections.
"Antibiotic resistance is one of our...
Wake Up To Breaking News!