Key areas of measles virus polymerase to target for antiviral drug development

ScienceDaily | 8/22/2019 | Staff
Measles is a highly contagious virus that can lead to serious health complications and death. It begins with a fever, cough, runny nose and red eyes followed by a rash of tiny, red spots that starts at the head and spreads to the rest of the body. Although declared eliminated in the United States in 2000, the Centers for Disease Control and Prevention says the U.S. is experiencing the greatest number of measles cases reported since the early 1990s.

While an effective vaccine exists, there has been a steady decline in the number of people being vaccinated against the measles virus. Most new cases were among unvaccinated individuals, making the development of an effective treatment strategy complementing vaccination a public health priority. There are no antivirals licensed to treat measles. The new study identified a novel protein interface in the polymerase complex that is pivotal for the regulation of polymerase activity, providing a new objective for target-based antiviral drug discovery.

Understanding - Mechanism - RNA - Polymerase - Advancement

"We have advanced current understanding of the underlying mechanism of viral RNA-dependent RNA polymerase advancement along the encapsidated genome -- a poorly understood and not well characterized mechanism -- by identifying and characterizing the dynamic interactions between its constituents," said Venice Du Pont, first author of the study and a Ph.D. candidate working in Dr. Richard Plemper's lab...
(Excerpt) Read more at: ScienceDaily
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