Repeated **** exposure promotes host resistance to infection in preclinical HIV model

ScienceDaily | 8/21/2019 | Staff
Omnista (Posted by) Level 3
Research previously reported by the laboratory of Luis J. Montaner, D.V.M., D.Phil., the Herbert Kean, M.D., Family Professor and director of the HIV-1 Immunopathogenesis Laboratory at Wistar's Vaccine & Immunotherapy Center, together with investigators at the University of Puerto Rico, showed in a 2015 paper how continued **** exposure in female sex workers resulted in changes in the cervicovaginal tissue that predicted an increased resistance to HIV infection. The current study directly addressed if **** could be a factor in resistance.

"While HIV infection has been with us for more than 30 years, this is the first study that describes how **** exposure over time could result in local tissue changes that limit HIV infection in humans," said Montaner, who is the lead author of the new study. "Apart from defining a new factor that may regulate HIV transmission, this unexpected finding could directly impact the design of future HIV vaccine studies that commonly recruit female sex workers. Currently, condomless sex is assumed to only promote the likelihood of infection. Our observation, however, raises the hypothesis that frequent **** exposure may potentially reduce HIV transmission."

Edmundo - N - Kraiselburd - PhD - Professor

Edmundo N. Kraiselburd, Ph.D., professor at the University of Puerto Rico (UPR), co-directed this research project and supervised the use of non-human primates (NHP) from the Caribbean Primate Research Center. NHPs are a principal pre-clinical research model used to test prophylactic anti-HIV interventions.

"This research clearly shows the valuable information the macaque model can provide when used to study what may determine HIV infections in humans," said Kraiselburd.

Study - Animals - Week - Weeks

In the study, animals were exposed to **** twice a week over 20 weeks with or without...
(Excerpt) Read more at: ScienceDaily
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