The loss of astrocytes, a supporting cell in the brain, was most prominent in the corpus callosum, a part of the brain that bridges the two hemispheres. Previous imaging studies have identified differences in the brains of people who stutter compared to those who do not. Furthermore, some of these studies in people have revealed structural and functional problems in the same brain region as the new mouse study.
The study was led by Dennis Drayna, Ph.D., of the Section on Genetics of Communication Disorders, at the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health. Researchers at the Washington University School of Medicine in St. Louis and from NIH's National Institute of Biomedical Imaging and Bioengineering, and National Institute of Mental Health collaborated on the research.
Identification - Changes - Stuttering - Brain - Disorder
"The identification of genetic, molecular, and cellular changes that underlie stuttering has led us to understand persistent stuttering as a brain disorder," said Andrew Griffith, M.D., Ph.D., NIDCD scientific director. "Perhaps even more importantly, pinpointing the brain region and cells that are involved opens opportunities for novel interventions for stuttering -- and possibly other speech disorders."
Stuttering is characterized by pauses and repeated or prolonged sounds, syllables or words, which disrupt the normal flow of speech. People who stutter know what they want to say, but they have trouble saying it. The condition is most commonly seen in young children who typically outgrow the problem. However, for 1 in 4 children who experience early stuttering, the condition persists as a lifelong communication problem. It is estimated that as many as 1% of adults in the United States are affected by stuttering.
Brain - Studies - People - Results - Drayna
"The brain imaging studies of people who stutter are important, but those results can only take us so far," said Drayna. One challenge, he said, is that the imaging...
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