Nuclear membrane Lem2 necessary for nuclear scaling

phys.org | 11/29/2018 | Staff
Kota79Kota79 (Posted by) Level 4
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The size of the nucleus, often described as the command center of a cell, is proportional to cellular size, resulting in a constant ratio of nuclear and cellular volumes throughout the cell cycle. Using a deceptively simple system, multinucleate cells rely on the relative amount of cytoplasm to govern nucleus size, causing the nuclear volume to change in concert with cell growth.

The nucleus is surrounded by an envelope that is part of a subcellular membrane network, with the nuclear membrane being continuous with the endoplasmic reticulum. It stands to reason then that as the nucleus increases or decreases in size, so too does the nuclear membrane. Yet the mechanisms controlling nuclear size and the contribution of the membrane to this process are largely unknown.

Study - Week - Nature - Communications - Research

In a study published this week in Nature Communications, a multinational research team from Hiroshima University and The Francis Crick Institute show that inner nuclear membrane protein Lem2 is key to nuclear size control in model eukaryotic organism Schizosaccharomyces pombe.

As lead author of the study, Dr. Kazunori Kume of Hiroshima University explains how the team zeroed in on Lem2 and confirmed its role in nuclear size control.

Deletion - Mutants - Membrane - Proteins - S

"We created deletion mutants of various inner nuclear membrane proteins in S. pombe and assessed any resulting changes in the nuclear...
(Excerpt) Read more at: phys.org
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