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Depending on the physiological or pathological conditions under consideration, cells can migrate as large and cohesive epithelial sheets. Whereas most of the previous works suggest that migratory mechanisms are strongly regulated by intercellular contacts, the impact of physical constraints on collective migration remains unclear.
A recent study led by Danahe Mohammed, a Ph.D. student at the time of this study, and Professor Sylvain Gabriele of the University of Mons in Belgium reports that the spatial confinement exerted by neighboring cells modulates the migration velocity of epithelial tissues. This work was published in the June 2019 issue of Nature Physics.
Gabriele - Team - Confinement - Tissues - Way
Gabriele's team reproduced the physiological confinement observed in living tissues in a very controlled way by using microfabrication techniques for generating adhesive microstripes. These in vitro models allow the researchers to confine individual epithelial cells on adhesive tracks with widths varying from five to 20 µm, without...
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