Using Pennsylvania birth records, the researchers found a correlation between pre-pregnancy body-mass index (BMI) in mothers and subsequent cancer diagnosis in their offspring, even after correcting for known risk factors, such as newborn size and maternal age. The final version of the paper published online today in the American Journal of Epidemiology.
"Right now, we don't know of many avoidable risk factors for childhood cancer," said lead author Shaina Stacy, Ph.D., postdoctoral scholar in the Pitt Public Health Department of Epidemiology and UPMC Hillman Cancer Center. "My hope is that this study can be, in a way, empowering and also motivating for weight loss."
Stacy - Colleagues - Birth - Records - Cancer
Stacy and colleagues pored through nearly 2 million birth records and about 3,000 cancer registry records filed in the state of Pennsylvania between 2003 and 2016 and found that children born to severely obese mothers -- BMI above 40 -- had a 57% higher risk of developing leukemia before age 5. Weight and height also were individually associated with increased leukemia risk.
Further analysis showed that it wasn't simply that larger...
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