Specific multinutrient combination benefits patients with early stage Alzheimer's disease

ScienceDaily | 6/12/2019 | Staff
Omnista (Posted by) Level 3
The purpose of this study was to assess whether this multinutrient combination can benefit patients with mild cognitive impairment who are at risk of progressing to the dementia stage of AD. Previous studies have shown that Fortasyn Connect® can have benefits in early AD.

"The initial asymptomatic phase (preclinical AD) continues into a prodromal phase with mild but noticeable cognitive impairment, yet with functional autonomy, with eventual further progression to dementia. This gradual progression creates a window of opportunity for intervention," explained lead investigator Maria Sagrario Manzano Palomo, MD, PhD, Department of Neurology, Infanta Leonor Hospital, Madrid, Spain. "Recent trials have involved multimodal, non-pharmacological approaches including dietary intervention, which is an important modifiable risk factor."

Study - Follow-up - June - December - Neurology

This longitudinal study, with a one-year follow-up, was carried out from June 2015 to December 2016 in the Neurology Department of Infanta Cristina Hospital, Madrid, Spain. Investigators recruited 43 patients with mild cognitive impairment and a mean age of 70. 58.5% of the patients were women.

Neuropsychological tests and 18F-FDG-PET imaging were conducted at the inclusion visit and checked again at the one-year follow-up, which also included a neurological examination and a Subjective Changing Scale completed by the caregiver. Seventeen patients received the product while 24 patients were in the group without intervention, and two patients withdrew.

Imaging - Studies - Measure - Number - Synapses

F-FDG-PET imaging studies provide a measure of the number of synapses in a brain region (this number decreases in mild cognitive impairment progressing to more advanced AD); the ability of this food for special medical purposes to impact this decrease in synaptic number was assessed.

18F-FDG PET scans showed a significant worsening in the group without nutritional intervention compared with the group receiving the product. There was a significant worsening in memory performance, executive functions and attention in the group without intervention, while the group receiving the product showed a stabilization in these...
(Excerpt) Read more at: ScienceDaily
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