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B cells play a central role in the immune system. When the body is confronted with an infection, they turn into plasma cells that release protective antibodies that both fight ongoing infections and prevent future ones. Unlike other cells of the immune system that have relatively short lifespans, plasma B cells can survive and continuously produce antibodies for decades.
Because plasma cells are so efficient at making and secreting proteins like antibodies they could be the ideal cell type to produce therapeutic proteins.
Dr - David - Rawlings - Dr - Richard
Dr. David Rawlings, Dr. Richard James and their colleagues in the research institute's Center for Immunity and Immunotherapies are among a small number of research groups in the U.S. dedicated to exploring how clinicians might some day use plasma cells to fight diseases in children. In a scientific first, a basic science research team led by Rawlings and James genetically reprogrammed human B cells to act as cell factories capable of delivering sustained, high doses of a therapeutic protein introduced by gene editing.
"Theoretically, the B cells we created could provide a long-term treatment for a wide range of diseases where the body lacks the ability to make a certain protein, like in the case of the bleeding disorder, hemophilia B," James said. "Such a cell therapy could also have broad applications for autoimmune conditions, where the introduced protein could be used to turn off abnormal immune responses, or to disarm infectious diseases by secreting known protective antibodies."
Question - Researchers - Reprogrammed - B - Cells
The other question researchers had to answer was whether or not the reprogrammed B cells would persist in the body after being introduced, and James and his team did just that.
James presented research at the 2019 American Society for Gene and Cell Therapy annual meeting that was the first to demonstrate that engineered human B cells can survive indefinitely in any model. To...
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