Characterization of the structure of a member of the L-Amino acid Transporter (LAT) family

ScienceDaily | 4/24/2019 | Staff
LATs form a family that includes various kinds of amino acid transporter and even even members in bacteria. Mutated LATs are associated with conditions as diverse as autism, age-related hearing loss, cystinuria and lysinuric protein intolerance.

Published in the journal Nature Communications, this study has focused on BasC, a LAT present in bacteria. "We have used BasC as a model because it shows structural and functional similarity to LATs in humans," explains Manuel Palacín, head of the Amino Acid Transporters and Disease Lab at IRB Barcelona.

Structure - Function - BasC - Authors - Work

By analysing the structure and function of BasC, the first authors of this work, Ekaitz Errasti-Murugarren, Joana Fort and Paola Bartoccioni, postdoctoral fellows at IRB Barcelona, have identified the site at which amino acids bind to LATs and the mechanism underlying the interaction at...
(Excerpt) Read more at: ScienceDaily
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