LATs form a family that includes various kinds of amino acid transporter and even even members in bacteria. Mutated LATs are associated with conditions as diverse as autism, age-related hearing loss, cystinuria and lysinuric protein intolerance.
Published in the journal Nature Communications, this study has focused on BasC, a LAT present in bacteria. "We have used BasC as a model because it shows structural and functional similarity to LATs in humans," explains Manuel Palacín, head of the Amino Acid Transporters and Disease Lab at IRB Barcelona.
Structure - Function - BasC - Authors - Work
By analysing the structure and function of BasC, the first authors of this work, Ekaitz Errasti-Murugarren, Joana Fort and Paola Bartoccioni, postdoctoral fellows at IRB Barcelona, have identified the site at which amino acids bind to LATs and the mechanism underlying the interaction at...
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