Scientists reproduce complete copy of 'anti-tumor antibiotic'

ScienceDaily | 4/24/2019 | Staff
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This major breakthrough and world-first could hail a new era in the design and production of new antibiotics and anticancer agents.

The 'super substance' -- kedarcidin -- was discovered in its natural form by a pharmaceutical company when they extracted it from a soil sample in India almost 30-years-ago. Soil is the natural source of all antibiotics developed since the 1940s but in order for them to be developed as potential drug treatments they must be produced via chemical synthesis.

Antibiotics - Bacteria - Kedarcidin - Cells - Cancer

Unlike many other antibiotics which focus solely on killing bacteria, kedarcidin is also capable of harming tumour cells and has potential as an effective cancer treatment.

Kedarcidin is incredible in its biological activity, as it works by causing DNA damage to its target, but also in its structural complexity. It has been the subject of extensive research by scientists around the world but because of its complex structure they have been unable to reproduce it in its most complete and accurate form, until now.

Dr - Martin - Lear - University - Lincoln

Dr Martin Lear at the University of Lincoln, UK, and Professor Masahiro Hirama, based at Tohoku University in Japan, have become the first scientists in the world to create a total synthesis of this highly unstable natural product. Their findings are published in The Journal of Antibiotics from Nature.

Dr Martin Lear, Reader in the School of Chemistry at the University of Lincoln, explained: "Following its discovery in soil it took 10 years to determine the molecular structure of...
(Excerpt) Read more at: ScienceDaily
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