Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may seem to have lost touch with reality and may suffer from hallucinations, delusions, disordered thinking, negative mood, and cognitive impairments. Research has shown that many different genes may increase the risk of schizophrenia and also that interactions between genes and aspects of the individual's environment, including exposure to viruses, malnutrition before birth, problems during birth, and/or psychosocial factors, are necessary for schizophrenia to develop.
Previous research has shown that preeclampsia, the most common pregnancy complication involving placental inflammation, is associated with developmental abnormalities in offspring that predispose them to a two- to four-fold increase in the risk for schizophrenia. Research has also shown that a lengthy period of prepregnancy vaginal exposure to the sperm of the offspring's father can overcome the maternal intolerance to paternal antigens that is a risk factor for preeclampsia.
Immune - Intolerance - Father - Sperm - Pathway
"We hypothesized that if maternal immune intolerance to the father's sperm is a component pathway of risk for schizophrenia, then the couples' duration of prepregnancy sexual contact could be related to the offspring's risk for schizophrenia," said Dolores Malaspina, MD, MS, MPH, Professor of Psychiatry, Genetics and Genomic Sciences, and Neuroscience at the Icahn School of Medicine at Mount Sinai and first author of the paper. "Our results conclude that offspring born to couples married for less than three years, across all paternal ages, harbor a small increased risk for schizophrenia, which was independent of parental psychiatric disorders and paternal age. We anticipate that this work will inspire many follow-up studies to examine this disease pathway."
A prior study conducted by Dr. Malaspina demonstrated an association between short durations of marriage and increased offspring risk for schizophrenia, with preeclampsia considered as the explanation. That study did not account for...
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