Making a fast ion transporter

phys.org | 4/15/2019 | Staff
kringkring (Posted by) Level 4
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An international team of researchers at Institute for Molecular Science in Japan and Max Planck Institute of Biophysics in Germany has revealed an ion transport mechanism of sodium/proton antiporter by simulating its motion. Based on the simulations, they have designed a faster transporter by making mutation on "gate" of the transporter.

Na+/H+ antiporters exchange sodium ions and protons across the cellular membrane to control pH, ion concentrations and cell volume, which is linked to a wide spectrum of diseases from heart failure to autism. Researchers have now designed a faster Na+/H+ antiporter based on the simulations.

Team - Researchers - Research - Associate - Kei-ichi

An international team of researchers, research associate professor Kei-ichi Okazaki at Institute for Molecular Science and groups of professors Gerhard Hummer and Werner Kühlbrandt at Max Planck Institute of Biophysics, have described an ion transport mechanism of the archaeal Na+/H+ antiporter PaNhaP in atomic detail using molecular dynamics simulations. Based on the simulations, they...
(Excerpt) Read more at: phys.org
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