The research, led by scientists and pediatric allergists at the University of British Columbia and BC Children's Hospital, is the first to demonstrate the safety of peanut oral immunotherapy for a large group of preschool-aged children when offered as routine treatment in a hospital or clinic rather than within a clinical trial.
"Although there have been many clinical trials of peanut oral immunotherapy in older children, and one trial in preschoolers, there has been a lack of real-world data due to safety concerns of offering this treatment to preschoolers outside of a research setting," said Lianne Soller, the study's lead author and allergy research manager at BC Children's Hospital. "But our findings confirm in a real-world setting that this treatment is not only safe but is well-tolerated in a large group of preschool-aged children."
Immunotherapy - OIT - Treatment - Protocol - Patient
Oral immunotherapy (OIT) is a treatment protocol in which a patient consumes small amounts of an allergenic food, such as peanut, with the dose gradually increased to a determined maximum amount. The goal typically is to reach desensitization, where a patient can ingest more of the allergenic food without triggering a dangerous reaction -- protecting them in the event of accidental exposure. Patients must continue to consume a determined amount of the allergen regularly as maintenance.
Allergists from across Canada followed 270 children who were given OIT for peanut allergy from April 2017 to November 2018. Children were between the ages of nine months and five years, and all were required to have a convincing diagnosis of peanut allergy made by an allergist.
Children - Allergist - Community - Hospital - Clinic
Children were seen by a pediatric allergist in a community or hospital clinic approximately every two weeks, where they were fed a peanut dose that gradually increased at every visit. Parents also gave children the same daily dose at home, between clinic visits, until they reached a...
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