Large multi-ethnic genome-wide association study of asthma identifies novel associations

ScienceDaily | 4/16/2019 | Staff
joseph76 (Posted by) Level 3
Asthma affects over 300 million persons globally and susceptibility to asthma is influenced by environmental and genetic risk factors. "Identifying the genetic variants associated with asthma through GWAS is crucial for determining the genetic basis of asthma" said co-first author Joanne Sordillo, ScD, MS, Research Scientist at the Harvard Pilgrim Health Care Institute. "It's also necessary to understand how genetic heterogeneity underlying asthma risk may be influenced by ethnic background, using large, multi-racial patient populations."

Researchers conducted an asthma GWAS in the Kaiser Permanente Northern California Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort, using a total of 68,623 asthma cases and non-asthmatic controls. Study results found a novel potential mechanism for asthma susceptibility by the gene, IL1RL1. Study investigators believe this could be associated with asthma susceptibility through...
(Excerpt) Read more at: ScienceDaily
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