Drug reduces risk of kidney failure in people with diabetes, study finds

ScienceDaily | 4/15/2019 | Staff
roxy2707 (Posted by) Level 3
"For the first time in 18 years, we have a therapy for patients with Type 2 diabetes and chronic kidney disease that decreases kidney failure," said Kenneth Mahaffey, MD, professor of medicine at the Stanford University School of Medicine and co-principal investigator of the trial. "Now, patients with diabetes have a promising option to guard against one of the most severe risks of their condition."

The trial involved 4,401 participants in 34 countries.

Drug - Canagliflozin - Therapy - Treatment - Kidney

The drug, canagliflozin, improves on a nearly two-decades-old therapy that is currently the only treatment approved to protect kidney function in people with Type 2 diabetes. In the trial, canagliflozin also was found to reduce the risk of major cardiovascular events.

Canagliflozin increases the excretion of glucose through the kidneys. It has already been approved by the Food and Drug Administration to lower blood glucose in patients with Type 2 diabetes and to reduce the risk of major adverse cardiovascular events in patients with Type 2 diabetes and existing heart disease.

Paper - Findings - CREDENCE - Trial - Today

A paper describing the findings of the CREDENCE trial was published today in The New England Journal of Medicine and presented at the International Society of Nephrology's World Congress of Nephrology in Melbourne. Mahaffey, who is director of the Stanford Center for Clinical Research, is the study's senior author. The lead author is Vlado Perkovic, MBBS, PhD, executive director of The George Institute for Global Health Australia, and a professor of medicine at the University of New South Wales in Sydney.

'Definitive trial result'

People - Diabetes - Kidney - Disease - Risk

"People with diabetes and kidney disease are at extremely high risk of kidney failure, heart attack, stroke and death," Perkovic said. "With this...
(Excerpt) Read more at: ScienceDaily
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