Promising cancer vaccine that teaches the body destroy tumours sends three patients into remission

Mail Online | 4/9/2019 | Vanessa Chalmers Health Reporter For Mailonline
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A cancer vaccine that teaches the body to fight tumours has put three lymphoma patients into remission.

The vaccine is injected directly into the tumour and teaches the immune system to destroy it, as well as seek other cancerous cells.

Researchers - Patients - Lymphoma - Remission - Months

Researchers tested it on 11 patients with lymphoma and said some were in full remission for months and even years.

Trials have been so successful that experts believe it offers hope for many other cancers, including those of the breast, head and neck.

Treatment - Vaccine - Cancer - Person - Immune

Although the treatment is called a vaccine, it doesn't prevent cancer. Instead, it teaches the person's immune system to fight disease.

Researchers at New York's Mount Sinai Hospital injected tumours with a stimulant that recruits immune cells called dendritic cells.

Tumour - Dose - Radiotherapy - Stimulant - Cells

After treating the tumour with a low dose of radiotherapy, a second stimulant was injected which activated the dendritic cells.

This then instructed T cells to kill cancerous cells throughout the body, while sparing non-cancerous cells, according to the study published in Nature Medicine.

Patients - Remission - Treatment - Shrunk - Tumours

This led to three of the patients to be put into remission as the treatment shrunk both the initial tumours targeted and other ones throughout their body.

People with lymphoma have abnormal lymphocytes - white blood cells that help fight infection - that have divided out of control.

Lymphocytes - Part - Body - Armpits - Neck

The lymphocytes can collect in any part of the body, most often in the armpits, neck or groin.

Lead author Dr Joshua Brody, director of the Lymphoma Immunotherapy Program at The Tisch Cancer Institute, said: 'The in situ vaccine approach has broad implications for multiple types of cancer.'

Lab - Tests - Mice - Vaccine - Success

In lab tests in mice, the vaccine drastically increased the success of...
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