How a major tumor suppressor pathway becomes deactivated

ScienceDaily | 4/4/2019 | Staff
Frost123Frost123 (Posted by) Level 3
Researchers now have found a new regulator of Hippo signaling that offers novel insights into how this critical signaling pathway becomes turned off in cancer cells.

"We have discovered that the enzyme STK25, a serine/threonine kinase, is a regulator of the Hippo tumor suppressor pathway," said corresponding author Neil J. Ganem, PhD, assistant professor of pharmacology and medicine, section of hematology and medical oncology, at Boston University School of Medicine (BUSM).

Researchers - Combination - Experiments - Cell - Lines

The researchers used a combination of experiments in both cell lines and experimental models to study how STK25 regulates Hippo signaling. They found Hippo signaling was significantly impaired when they removed STK25 in cell lines. They also found this to be the case in models in which STK25 was genetically deleted. By studying cancer genetics databases,...
(Excerpt) Read more at: ScienceDaily
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