New study identifies genetic variant that could help reduce need for liver transplants

ScienceDaily | 4/3/2019 | Staff
sally140353 (Posted by) Level 3
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Researchers studied the role and mechanisms of a genetic variation in the MICA gene, a gene that is induced when cells are damaged.

The research team were able to show that, in 1,689 patients with chronic hepatitis C, the MICA gene variant rs2596542 is associated with the progression and severity of liver fibrosis.

Rs2596542 - Triggers - Response - Rate - Liver

They believe this occurs because rs2596542 triggers an immune response that increases the rate of liver fibrosis in patients with chronic hepatitis C infection.

First author of the study, Dr Rasha El Sharkawy said, "Understanding how and why liver fibrosis occurs is crucial for preventing health complications in those at risk.

Hepatitis - C - Fibrosis - Carcinoma - HCC

"Chronic hepatitis C, liver fibrosis and hepatocellular carcinoma (or HCC -- the most common form of primary liver cancer) are all serious conditions that are closely linked.

"Chronic hepatitis C is a major risk factor for liver cirrhosis (advanced liver fibrosis), and a leading cause of HCC in Australia. Liver scarring and chronic hepatitis C are both conditions that can lead to a liver transplant.

Rate - Fibrosis - Differs - Person - Person

"The rate of fibrosis differs from person to person, so understanding the genetics behind liver fibrosis...
(Excerpt) Read more at: ScienceDaily
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