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In this edition of CrAMed, our academic additive manufacturing digest, we bring you the latest literature on metamaterials, 4D printing, regenerative medicine, multimaterial 3D printing and more from leading institutions around the globe.
In recent years, 3D printing has helped make important breakthroughs in regenerative medicine and tissue engineering. Continuing this trend, in a recently published paper, Mexican researchers found a way to enhance the mechanical properties of 3D printable alginate hydrogels.
Hydrogels - Team - Titanium - Dioxide - TiO2
Reinforced hydrogels are created by the team by adding titanium dioxide (TiO2) and β-tricalcium phosphate (β-TCP). With these additions, they were able to increase the material’s elastic modulus up to 20 MPa. The added elasticity gives the material more support to cell scaffolds, particularly those for bone regrowth due to the β-TCP (hydroxyapatite) content.
According to the authors, “The study provides new insights into the possibilities of alginate/gelatin added with TiO2 nanoparticles and β-TCP composite hydrogel 3D printing for tissue regeneration, where further assays are being made to prove cytotoxicity, cell proliferation, and bioactivity of the material.”
Procedure - Hydrogel - Paper - Alginate/Gelatin - Hydrogels
The procedure for creating reinforced hydrogel is described in the paper “Alginate/Gelatin Hydrogels Reinforced with TiO2 and β-TCP Fabricated by Microextrusion-based Printing for Tissue Regeneration” published in Polymers journal.
Various scaffold designs 3D printed in the study. Image via MDPI.
University - Washington - J - J - Schwartz
At the University of Washington, J. J. Schwartz & A. J. Boydston have shown how multi-material 3D printing is possible with a DLP printer. The paper titled “Multimaterial actinic spatial control 3D and 4D printing” details the findings of the study.
Multi-material 3D printing using a resin-based machine has been accomplished before, but according to the researchers, previous works had limiting factors. For example, in earlier studies using DLP, it was only possible to 3D print a multi-material object on the z-axis but not on x and y-axes.
Methods - Material - Vat
Such methods also required changing the material in the vat during...
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