Thermally abused frying oil -- cooking oil that has been repeatedly reheated to high temperatures -- may act as a toxicological trigger that promotes tumor cell proliferation, metastases and changes in lipid metabolism, scientists at the University of Illinois found. They reported their findings in the journal Cancer Prevention Research.
After consuming a low-fat diet for one week, one group of the mice was fed unheated fresh soybean oil, while another group consumed thermally abused oil for the next 16 weeks. Soybean oil was used in the study because of its common use by the food service industry in deep frying.
U - I - Scientists - Breast - Cancer
The U. of I. scientists simulated late-stage breast cancer by injecting 4T1 breast cancer cells into a tibia of each mouse. The 4T1 cells are an aggressive form of the disease that can spontaneously metastasize to multiple distant sites in the body, including the lungs, liver and lymph nodes, according to the study.
Twenty days after inoculation with the tumor cells, the primary tumors in the tibias of the mice that consumed the thermally abused oil had more than four times as much metastatic growth as the mice that consumed the fresh soybean oil. And when the researchers examined the animals' lungs, they found more metastases among those that consumed the thermally abused oil.
Tumors - Lung - William - G - Helferich
"There were twice as many tumors in the lung, and they were more aggressive and invasive," said William G. Helferich, a professor of food science and human nutrition, who led the research.
Food chemistry professor Nicki J. Engeseth, the acting head of the department, co-wrote the paper. Graduate student Ashley W. Oyirifi and U. of I. alumnus Anthony Cam were the lead authors.
Nodules - Lungs - Clones - Transformation - Metastases
"I just assumed these nodules in the lungs were little clones -- but they weren't. They'd undergone transformation to become more aggressive. The metastases in the fresh-oil group...
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