Novel protein degradation pathway

ScienceDaily | 3/12/2019 | Staff
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A Florida State University research team has uncovered one such mystery -- how a type of protein that is embedded in the inner nuclear membrane clears out of the system once it has served its purpose. Understanding that process may have implications for a class of human diseases including muscular dystrophy.

FSU graduate student Bailey Koch, working in the lab of Associate Professor of Biological Science Hong-Guo Yu, led the work.

Research - Puzzle - Koch - Yu - Undergraduate

"This research is like a puzzle," said Koch, who also worked for Yu as an undergraduate. "This study is a small piece, but it's a piece that we and others can build on going forward."

Koch and Yu examined the build-up of proteins around the nuclear membrane. These proteins are vital to a number of biological functions, but researchers were searching for clues about how old proteins were cleared out once they ceased to function.

Answer - Journal - Cell - Biology - Koch

The answer is published in the Journal of Cell Biology. Koch and Yu found that a type of enzyme that typically regulates cell cycle progression is responsible for the breakdown of the protein Mps3, an integral inner nuclear membrane protein that is an essential component linking the nucleoskeleton to the cytoskeleton.

Koch, who presented the research at the American Society of Cell Biology/European Molecular Biology...
(Excerpt) Read more at: ScienceDaily
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