Researchers discover a novel protein degradation pathway

phys.org | 3/12/2019 | Staff
entengoentengo (Posted by) Level 3
Click For Photo: https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/hires/2019/fsuresearche.jpg

The nucleus is a treasure trove of biological information that keeps the cell—and thus living organisms—ticking. But many processes within the nucleus remain a mystery to scientists.

A Florida State University research team has uncovered one such mystery—how a type of protein that is embedded in the inner nuclear membrane clears out of the system once it has served its purpose. Understanding that process may have implications for a class of human diseases including muscular dystrophy.

FSU - Graduate - Student - Bailey - Koch

FSU graduate student Bailey Koch, working in the lab of Associate Professor of Biological Science Hong-Guo Yu, led the work.

"This research is like a puzzle," said Koch, who also worked for Yu as an undergraduate. "This study is a small piece, but it's a piece that we and others can build on going forward."

Koch - Yu - Build-up - Proteins - Membrane

Koch and Yu examined the build-up of proteins around the nuclear membrane. These proteins are vital to a number of biological functions, but researchers were searching for clues about how old proteins were cleared out once they ceased to function.

The answer is published in the Journal of Cell Biology. Koch and Yu found that a type of enzyme that typically regulates cell cycle progression is responsible for the breakdown of the protein Mps3, an integral inner nuclear membrane protein that is an essential component linking the nucleoskeleton to the cytoskeleton.

Koch - Research

Koch, who presented the research at the...
(Excerpt) Read more at: phys.org
Wake Up To Breaking News!
Sign In or Register to comment.

Welcome to Long Room!

Where The World Finds Its News!