Ganesh Halade, Ph.D., and colleagues at the University of Alabama at Birmingham and other institutions have investigated how aging and an obesity-generating omega 6-enriched diet impact microflora in the gut, the structure and function of the spleen, and a subsequent immune response to heart attack, using a mouse model.
In a study published in the FASEB Journal, they report that a calorie-dense, obesity-generating diet in aging mice disrupted the composition of the gut microbiome, and that correlated with development of a systemwide nonresolving inflammation in acute heart failure, with disruptions of the immune cell profile -- notably the neutrophil-leukocyte ratio.
Halade - Associate - Professor - Division - Cardiovascular
Halade is an associate professor in the Division of Cardiovascular Disease, UAB Department of Medicine.
It is known that diet interacts with gut microbes to calibrate the body's immune defense capacity. The UAB-led researchers examined this further, with regard to aging and a high-fat diet.
Diet - Increase - Bacteria - Genus - Allobaculum
They found that the obesity-generating diet caused a sharp increase in bacteria belonging to the genus Allobaculum, phylum Firmicutes. The obesity-generating diet also increased the proportion of neutrophils in the blood of young mice. In aged mice, a similar increase in the proportion of neutrophils was found...
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