Identification of the genetic factors involved in this loss of limbs is a focus of the article "Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution" published by Juliana Gusson Roscito and collaborators in Nature Communications.
Another equally interesting focus of the article is eye degeneration in certain subterranean mammals.
Cases - Order - Process - Changes - Evolution
"We investigated these two cases in order to understand a much more general process, which is how genome changes during evolution lead to phenotype changes," Roscito told.
Currently working as a researcher at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, Germany, Roscito has been a postdoctoral fellow in Brazil and a research intern abroad with São Paulo Research Foundation -- FAPESP's support. Her postdoctoral scholarship was linked to the Thematic Project "Comparative phylogeography, phylogeny, paleoclimate modeling and taxonomy of neotropical reptiles and amphibians," for which Miguel Trefaut Urbano Rodrigues is the principal investigator under the aegis of the FAPESP Research Program on Biodiversity Characterization, Conservation, Restoration and Sustainable Use (BIOTA-FAPESP).
Rodrigues - Full - Professor - University - São
Rodrigues is a Full Professor at the University of São Paulo's Bioscience Institute (IB-USP) in Brazil and supervised Roscito's postdoctoral research. He is also a coauthor of the recently published article.
"The research consisted of an investigation of the genomes of several species of vertebrates, including the identification of genomic regions that changed only in snakes or subterranean mammals, while remaining unchanged in other species that have not lost their limbs or have normal eyes," Roscito said.
Mammals - Systems - Genes - Eye - Crystalline
"In mammals with degenerated visual systems, we know several genes have been lost, such as those associated with the eye's crystalline lens and with the retina's photoreceptor cells. These genes underwent mutations during the evolutionary process. Eventually, they completely lost their functionality, meaning the capacity to encode proteins. But that's not what happened to snakes, which haven't lost the...
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