"Many potential new drugs fail because of toxicity issues, and cardiac toxicity is a major challenge," says Professor Milica Radisic, who led the research team. "You can test potential drugs on heart cells grown in a petri dish, but those cells don't look the same as the cells in a real heart, and you can't get much information about their actual cardiac function."
Radisic and her collaborators build devices that enable lab-grown cells and tissues to develop into 3D forms that more closely resemble those in the human body. Five years ago, they created the Biowire, a platform in which heart cells grow around a silk suture. By pulsing electricity through the cells, the device causes them to elongate and become more like mature human heart cells.
Paper - Today - Cell - Platform - Biowire
Their latest paper, published today in Cell, describes a new platform dubbed Biowire II. It contains two wires made of elastic polymers and positioned three millimetres apart, with heart cells forming a small band of tissue between them. Each time the cells contract, they bend the wires. By measuring the amount of deflection in the wires, the researchers can determine the force of the contraction.
"The advantage of this system is that it tells us how a given drug molecule is affecting the cardiac output by examining forces of contraction and other key functional readouts," says Yimu Zhao, a PhD candidate in Radisic's lab and the lead author on the paper. "Does it weaken the heart or make it stronger? It will help find new drugs to treat heart conditions, but also eliminate drugs for other conditions that have adverse effects on the heart."
Biowire - Pulses - Exercise - Train - Heart
As with the original Biowire, electrical pulses are used to simulate exercise and "train" the heart cells. Zhao says the team has refined the training regimen to create tissue that is even more...
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