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Five monkey clones have been born with genetic conditions from a gene-edited animal in China.
The animals are genetically identical to one another and the donor monkey that was cloned.
Affliction - Deliberate - Muting - Region - BMAL1
All five have the same affliction pertaining to the deliberate muting of a DNA region known as BMAL1 which is involved in producing certain proteins,
Animals can survive with this deactivated but suffer from circadian disorder characteristics such as lack of sleep, anxiety, depression and schizophrenia-like behaviour.
Researchers - Foundation - Population - Primates - Use
Researchers claim this will lay the foundation for creating a population of 'customised' gene-edited primates for use in research.
The animals will be destined for a life in a laboratory and used to study the effectiveness of treatments for a range of human conditions.
Scientists - Process - Animal - Right - Symptoms
Scientists hope that by repeating this process they can create one animal that exhibits the right symptoms and then use this as the future blueprint for all clones.
The groundbreaking quintet were born at the Institute of Neuroscience (ION) of the Chinese Academy of Sciences (CAS) in Shanghai.
Cells - Donor - Monkey - Clones
Cells from a donor monkey were used to create the clones.
A process known as somatic cell nuclear transfer (SCNT) was used to create the animals and it is the same procedure used to generate Zhong Zhong and Hua Hua, the first two cloned monkeys, and Dolly the sheep back in 1996.
Scientists - Advance - Online - National - Science
Chinese scientists say the advance, reported online by the journal National Science Review, said the cloned quintet showed signs of a wide-range of symptoms associated with the loss of BMAL1.
The donor animals had this section of DNA deactivated via the famed gene-editing technique Crispr-Cas9.
Tool - Scientists - Material - Changes - Generations
This powerful tool allows scientists to manipulate genetic material and the changes are permanent and passed on down the generations.
It is also the technique allegedly used by Dr He Jiankui in China to create...
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