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Scientists around the globe are trying to pinpoint potential drug targets to stop Ebola virus disease, a hemorrhagic fever that killed 382 people in the latest outbreak in the Democratic Republic of Congo in 2018. Thousands of people have died from Ebola since an outbreak erupted in West Africa four years ago.
Texas Biomed Staff Scientist Olena Shtanko, Ph.D., describes this new work as a "turning point for understanding how replication of Ebola virus is modulated." Her role in the project was to validate and test whether the interaction between an Ebola virus protein called VP 30 and a host (human) protein called RBBP6 had involvement in the life cycle of the virus. Dr. Shtanko worked on this project while in the lab of Dr. Robert Davey, a former Texas Biomed Scientist, now at Boston University.
Research - Scientists - California - Interaction - Map
Earlier research by scientists in California used a protein interaction map to narrow down host and virus protein interactions and then using a yeast system and an artificial proxy virus system proved the theory of this particular protein-protein interaction. However, scientists needed to use replicating virus and human immune cells to test the clinical significance of the finding.
"The interaction is important if you can show functional significance of what it does to the virus in cells that have clinical relevance," Shtanko stressed. "If you can figure out the mechanism within these cells, then you can potentially manipulate it and stop the disease progression."
Texas - Biomed - Staff - Scientist - Eusondia
Texas Biomed Staff Scientist Eusondia Arnett, Ph.D.,...
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