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"We know that MANF, which regulates metabolism and immune response in flies, mice and humans, declines with age," said senior author Heinrich Jasper, PhD, a Buck professor and staff scientist at Genentech. "This research shows that replenishing MANF has promise as an anti-aging treatment although much work remains to be done in order to understand its mechanism of action."
While researchers have yet to understand why MANF levels decrease with age, Jasper says MANF deficiency has obvious hallmarks. Flies genetically engineered to express less MANF suffered from increased inflammation and shorter lifespans. MANF-deficient mice had increased inflammation in many tissues as well as progressive liver damage and fatty liver disease. Older mice who shared blood with MANF-deficient younger mice did not benefit from the transfusion of young blood.
Buck - Fellows - Pedro - Sousa-Victor - PhD
Buck postdoctoral fellows Pedro Sousa-Victor, PhD, and Joana Neves, PhD, were co-leaders of the study. They zeroed in on MANF and its impact...
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