The team's research results were published in the Journal of Antimicrobial Chemotherapy.
Colistin, an old antibiotic discovered in 1950, kills or inhibits the growth of Gram-negative bacteria, such as E. coli and Pseudomonas aeruginosa. It is one of the few critical antibacterial drugs for treating multidrug-resistant bacteria and is listed on the WHO Essential Medicines List (EML) as a last-resort antibiotic.
Colistin-resistance - Mutations - Frequency - Level - Colistin-resistance
Colistin-resistance is mostly related to chromosomal mutations. Although its frequency was low, a certain level of colistin-resistance was observed. However, since colistin-resistance caused by mutations was not transferred to other bacterial species, it was not considered problematic. However, a transmissible colistin resistance gene (mcr) was discovered in China in 2015 and the possibility of the transfer of colistin-resistance to other bacterial species was shown, becoming a global concern. This presents the potential danger that carriage of mcr1 gene in pathogens with other resistance genes will produce super drug-resistant bacteria called "Nightmare bacteria." This bacteria exhibits resistance to...
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