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The team of prof. Joris Messens at the VIB-VUB Center for Structural Biology has provided new insights into the regulation of an important intracellular messenger molecule, hydrogen peroxide (H2O2), whose dysregulation has been linked to the development of several diseases, including cancer.
To fine-tune levels of H2O2, cells can sense changes in the concentration of H2O2 and respond by activating specific DNA regulation mechanisms. In bacteria, a protein called OxyR functions as such a H2O2-sensor. The exact mechanism of how OxyR senses H2O2 and changes its DNA binding properties, however, has hitherto remained unexplored.
Structures - Experiments - Dr - David - Young
By combining protein X-ray crystal structures with supporting molecular biological and biochemical experiments, Dr. David Young and Dr. Brandán Pedre together with international collaborators and co-workers of the Messens lab have provided new insight into this question. They have uncovered the precise H2O2 binding site and the conformational changes that OxyR uses to...
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