New research could fine-tune the gene scissors CRISPR

ScienceDaily | 11/29/2018 | Staff
idkwatitis (Posted by) Level 3
However, in a new study published in the scientific journal Cell researchers from the Novo Nordisk Foundation Center for Protein Research have described how one of the CRISPR technologies, the so-called Cas12a, works -- all the way down to the molecular level. This makes it possible to fine-tune the gene-editing process to only achieve the desired effects.

'If we compare CRISPR to a car engine, what we have done is make a complete 3D map of the engine and thus gained an understanding of how it works. This knowledge will enable us to fine-tune the CRISPR engine and make it work in various ways -- as a Formula 1 racer as well as an off-road truck', says Professor Guillermo Montoya from the Novo Nordisk Foundation Center for Protein Research.

Researchers - Cryo-electron - Microscope - Technology - CryoEM

The researchers have used a so-called cryo-electron microscope to map the technology. The recently inaugurated cryoEM facility at the University of Copenhagen has established the state-of-the-art technology enabling the researchers to take photographs of the different shapes of the molecule when CRISPR-Cas12a cuts up the DNA strand.

They combined it with a fluorescent microscopy technique called...
(Excerpt) Read more at: ScienceDaily
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