"We demonstrate a connection between the gut, the brain, and brown tissue, uncovering a previously unknown facet of the complex regulatory system controlling energy balance," says lead author Martin Klingenspor, chair of molecular nutritional medicine at the Technical University of Munich. "The view of brown fat as a mere heater organ must be revised, and more attention needs to be directed towards its function in the control of hunger and satiation."
During a meal, signals encoded by gut hormones reach the brain via the blood or through nerves activated in the small intestine. The work by Klingenspor and colleagues indicates that the gut hormone secretin -- first recognized in 1902 to stimulate the pancreas to secrete bicarbonate to help the small intestine neutralize acid and digest macronutrients -- has an underappreciated role in satiation.
Study - Mice - Secretin - Appetites - Mice
In their study, hungry mice that were injected with secretin had suppressed appetites. Injecting mice with secretin also increased the amount of heat that their brown fat produced. Mice with inactivated brown fat tissue, however, didn't experience the same appetite suppression when they were injected with the hormone --...
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